PhD Stipendium in Medizin (Universitätsklinikum Erlangen)

Medizin 3 25.025 Stunden auf 36 Monate befristet ab 01.03.2025 Eingruppierung gemäß TV-L Bewerbungsfrist 15.02.2025 Universitätsklinikum Erlangen Medizinische Klinik 3 - AG Bergmann Dr. med. Christina Bergmann Ulmenweg 18 91054 Erlangen Ansprechperson bei Fragen Dr. med. Christina Bergmann Senior Physician Phone: 09131 85 43114 Veröffentlicht seit: 16.12.2024 Job-Nr.: 9573 Hinweise für Bewerbende Jetzt bewerben Klingt spannend? Das sind wir: We are an international and dynamic laboratory for translational fibrosis research. Our overarching aim is to delineate molecular mechanisms of tissue remodelling in fibrosing disorders as basis for novel therapeutic strategies. Systemic Sclerosis is our central model disease. We have a strong translational focus, which is also reflected in the tight collaboration of scientists and physician scientists within the group. Group leaders have more than 10 years clinical and scientific experience in the field and we cooperate with national and international partners in academics. Your tasks: We are looking for a highly motivated PhD student (f/m/d) to work on a project focusing on mechanisms of tissue remodeling in Systemic Sclerosis as fibrosing model disease. Fibrosing diseases impose major socioeconomic burdens on modern societies and account for up to 45% of deaths in the developed world. Despite the huge medical need and first approved therapies the morbidity and mortality remain very high. New treatment options such as CD19.CART therapy offer new ways of deep immunosuppression. In this project we aim to characterize the mechanisms of CD19 mediated tissue remodeling compared to state-of-the art treatments. The student (f/m/d) will work on established state-of the art techniques of molecular biology including immunofluorescence, RNA seq, Western blot, nucleofection and siRNA, reporter assay, ChIP assay. The student will also be involved in establishing novel analysis and imaging methods. Working with mouse experiments is optional. Essential experience/ qualifications: Graduation at a Master´s level (or equivalent) in biological or biomedical sciences with convincing results Strong interest in biomedical research, in discovering new fields and establishing novel techniques Strong interest to work both independently and co-operatively within an international research team At least basic bioinformatic knowledge Good written and spoken English skills Additionally beneficial are: experience in state of the art techniques of molecular biology and cell culture Was meinen Sie? Passen wir zu Ihnen und Sie zu uns ans Uniklinikum Erlangen? Jetzt bewerben Arbeiten am Puls der Medizin Sinnvoll und systemrelevant Berufliche Perspektiven Vorteile eines Tarifvertrages Wenn Sie sich auf diese Stelle bewerben, erwähnen Sie bitte dass Sie sie auf Universitoxy gesehen haben.

Medizin 3

25.025 Stunden

auf 36 Monate befristet

ab 01.03.2025

Eingruppierung gemäß TV-L

Bewerbungsfrist 15.02.2025

Universitätsklinikum Erlangen
Medizinische Klinik 3 - AG Bergmann
Dr. med. Christina Bergmann
Ulmenweg 18
91054 Erlangen

Ansprechperson bei Fragen
Dr. med. Christina Bergmann
Senior Physician
Phone: 09131 85 43114

Veröffentlicht seit: 16.12.2024
Job-Nr.: 9573

Hinweise für Bewerbende

Jetzt bewerben

Klingt spannend?
Das sind wir:

We are an international and dynamic laboratory for translational fibrosis research. Our overarching aim is to delineate molecular mechanisms of tissue remodelling in fibrosing disorders as basis for novel therapeutic strategies. Systemic Sclerosis is our central model disease. We have a strong translational focus, which is also reflected in the tight collaboration of scientists and physician scientists within the group. Group leaders have more than 10 years clinical and scientific experience in the field and we cooperate with national and international partners in academics.

Your tasks:

We are looking for a highly motivated PhD student (f/m/d) to work on a project focusing on mechanisms of tissue remodeling in Systemic Sclerosis as fibrosing model disease. Fibrosing diseases impose major socioeconomic burdens on modern societies and account for up to 45% of deaths in the developed world. Despite the huge medical need and first approved therapies the morbidity and mortality remain very high. New treatment options such as CD19.CART therapy offer new ways of deep immunosuppression. In this project we aim to characterize the mechanisms of CD19 mediated tissue remodeling compared to state-of-the art treatments.

The student (f/m/d) will work on established state-of the art techniques of molecular biology including immunofluorescence, RNA seq, Western blot, nucleofection and siRNA, reporter assay, ChIP assay. The student will also be involved in establishing novel analysis and imaging methods. Working with mouse experiments is optional.

Essential experience/ qualifications:

Graduation at a Master´s level (or equivalent) in biological or biomedical sciences with convincing results
Strong interest in biomedical research, in discovering new fields and establishing novel techniques
Strong interest to work both independently and co-operatively within an international
research team
At least basic bioinformatic knowledge
Good written and spoken English skills